Brand Name(s):Seroquel, Seroquel, Quetiapine
Generic Name(s):Quetiapine Fumarate
Drug Class:An antipsychotic drug
Purpose:Treatment of schizophrenia
Dosage form(s):Tablets, oral tablets, extended-release tablets
Antipsychotic
Use in Adults:
Dosage forms(s):
Interactions:No significant interactions with other medications
directions for use:Avoid contact with eyes or mucous membranes, especially when fasting
Warnings
Dosage
Initial dose as an oral tablet (10 to 20 mg) taken once daily for up to 7 days. If needed, the dose may be increased to 20 mg once daily by increments of 5-10 mg. If no improvement in efficacy is observed after 12 weeks, the dose should be gradually reduced to less than 10 mg once daily
Maintenance dose as an oral tablet (10 to 20 mg) for up to 7 days.
The maximum recommended dose is 20 mg/day. If symptoms of hyperglycemia occur, the dose should be gradually reduced to 5 mg once daily to prevent hypoglycemia. In adults, the dose should be gradually reduced to less than 5 mg once daily to prevent hypoglycemia
Interactions
Metformin may increase the effectiveness of antidiabetic agents. It should not be used with metformin monotherapy or with combination therapy with insulin or other agents that increase the risk of diabetes.
In patients with liver disease, metformin may increase the efficacy of antidiabetic agents.
Use in Adults
Initial dose in adults. If clinical effects are not observed, the dose may be increased to an initial daily dose of 20 mg/day, as in schizophrenia.
Therapeutic Category:
Administration
May be taken with or without food.
For patients with severe renal impairment (creatinine clearance <30 mL/min) or severe hepatic impairment (including patients receiving concomitant use of metformin and other hepatotoxic agents) the initial dose should not be increased more than the maximum recommended dose. Renal impairment should be carefully evaluated for creatinine clearance <30 mL/min and proteinuria <20mL/kg/hour.
Dose adjustment for patients receiving concomitant administration of at least 10 mg of antipsychotic agent. Dose adjustments to reduce the risk of metabolic complications may be required.
For elderly patients (see Dosage for Precautions).
Contraindications
Hypersensitivity to the active substance or to any of the excipients listed at the end of this leaflet.
Special Precautions
Medications may interact with certain foods and beverages, so they may affect how well these medications work. You might find that certain foods and beverages can affect how well the medications work. Let’s talk about some of the possible interactions that can cause side effects.
You’ve probably heard of some medications that can interact with, including some that may be used for heart and blood vessel disorders.
Some medications, such as the antipsychotic medication,, may interact with the medications, causing changes in how well they work.
The following is a list of some of the possible interactions that could cause side effects. Please note that this list isn’t comprehensive and should only be used as guidance. Always consult with your doctor or pharmacist for more information.
Many of the medications that can cause these side effects are also listed below:
Some medications can interact with other drugs, such as:
Some of the medications that can cause these side effects are listed below:
This list isn’t comprehensive and should only be used as guidance.
AstraZeneca’s schizophrenia drug,trusted by millions of Americans, has come under scrutiny for its use and the risk it poses to children.
The drug, a Seroquel extended release tablet, is often prescribed to patients who have conditions like schizophrenia or bipolar disorder. Doctors have prescribed it as a second-line treatment for depression and anxiety.
But it may not be the only option for patients with schizophrenia or bipolar disorder. AstraZeneca’s Seroquel is the only drug in its class that’s being given off-patent for the treatment of people with a mental disorder.
The company says it is working on a clinical trial that will test the drug’s effect on children. But it isn’t clear how much of an effect it’s getting.
Doctors aren’t sure how many kids the drug would get off-patent.
Seroquel works by binding to dopamine receptors in the brain. This means it can block the effects of other medications and improve symptoms for children who have a disorder.
It’s a big question for AstraZeneca because, unlike other medications, it won’t be approved for use in children until 2020.
The company has a marketing plan that includes the drug’s approval in the United States.
AstraZeneca’s Seroquel has been on the market in the U. S. for some time. However, the drug has not been approved for use in children.
The drug’s maker, GlaxoSmithKline Plc, says it is working on a clinical trial for children who have schizophrenia and bipolar disorder.
Glaxo is also working on a clinical trial to evaluate the drug’s effectiveness.
AstraZeneca says it will have to submit data for the drug’s efficacy and safety in children and adolescents.
It’s not clear how much the drug’s use will be in children.
AstraZeneca said in a statement: “The Seroquel study did not demonstrate a significant improvement in the children’s symptoms.”
AstraZeneca’s Seroquel is the company’s second-line treatment for schizophrenia and bipolar disorder.AstraZeneca said in a statement: “This study was conducted on children with schizophrenia who were prescribed Seroquel for the condition.
“The findings suggest that the use of this medication in children with schizophrenia is not associated with any clinically significant benefit.”
AstraZeneca said it has “reviews” of children who have been prescribed Seroquel for bipolar disorder. It says it plans to release a new clinical trial in the coming weeks.
In a statement, AstraZeneca said it is reviewing the results of the trial. It said it is working to determine how well the drug works.
It said in a statement: “We are disappointed that we cannot provide further information on this study.
“As a result, the company is reviewing our studies for any new information.”
The company said it also is reviewing the results of a clinical trial.
If the results of the study are found to be inconclusive, the company is reviewing the trial.
AstraZeneca said it will update its website on the safety and efficacy of Seroquel in children and adolescents.
For more information, visit the company’s.
This story has not been edited by the time of the publication. Copyright 2012. All Rights Reserved.
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The article has not been edited by the time of the publication of this article.Read the article:
AstraZeneca’s Seroquel “is the only treatment in its class of atypical antipsychotics for adults with schizophrenia and bipolar disorder,” said David L. Leavitt, AstraZeneca’s chief executive officer. He said AstraZeneca “has received approval from the US Food and Drug Administration (FDA) for the treatment of this condition, and will be evaluating the drug in patients with schizophrenia and bipolar disorder.Salt Composition in both
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Seroquel XR 300mg(same for both)
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